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TILDEN RESEARCH LAB:

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BRAIN CELL GROWTH AND DEVELOPMENT

We study the influence of hormones, neurotransmitters, and environmental stress on the growth of neurites (axons and dendrites) in crustacean neurons.  Crustacean neurons are ideal biomedical models of neurodegenerative diseases such as Parkinson's and Alzheimer's.  They are structurally and functionally similar to human brain cells and respond similarly to oxidative stress, a factor in many neurological diseases.  We are studying the protective and proliferative influences of MELATONIN, a hormone involved in regulating the circadian and seasonal timing of numerous physiological processes. 
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Jan Plan 2008: Advanced Neuro Research BI474

MDIBL Summer Sunset: view from the lab 

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Jan Plan 2008: BI474 Advanced Neurobiology Research, Mount Desert Island Biological Laboratory

Sponsored by NIH Grant Number P20 RR-016463 from the INBRE Program of the National Center for Research Resources 

Crustacean X-organ Cell

Phase Contrast, 24 hr neurite growth

Labeled for MT1 melatonin receptors (green)

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